总之，大多数学者认为，关节软骨是人体免疫应答的免疫疫区，是免疫损伤导致的创伤性骨关节炎的发生［9］。本实验可以检测到大量增多的炎性因子，我们认为可能是由于关节软骨在损伤后导致软骨胶原纤维的断裂，从而炎性因子浸入，引起炎性反应，最终导致创伤性骨关节炎的发生，但具体的途径还有待于进一步的研究。
【参考文献】
［1］XIAOWEI L I, ROGER C H, NICHOLAS J A. An analytical model to study blunt impact response of the rabbit P-F joint［J］. J Biomech Eng, 1995,117:485-491.
［2］BUCKWALTER J A. Articular cartilage injures［J］. Clin Orthop, 2002,14(2):134-141.
［3］LOENING A M, JAMES I E, LEVENSTON M E, et al. Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis［J］. Arch Biochem Biophys, 2000,381:205-212.
［4］ZANG H, VRAHAS M S, BARATTA R V, et al. Damage to rabbit femoral articular cartilage following direct impacts of uniform stresses: an in vitro study［J］. Clin Biomech, 1999,14:543-548.
［5］MARTIN J A, BUCKWALTER J A. The role of chondrocyte-matrix interactions in maintaining and repairing articular cartilage［J］. Bimhemogy, 2000,37:129-140.
［6］WANG HAI-JUN, YU CHANG-LONG, HIROYUKI KISHI, et al. Effect of both IL-1 and TNF-α blockade for experimental osteoarthritis［J］. Chin J Sports Med, 2006,25(5):551-554.
［7］YU C L, QU M Y, TIAN D X, et al. Early articular cartilage changes in traumatic osteoarthritis［J］. J Orthop Surg, 1998,6(1):41-47.
［8］LEFRANC F, GOLZARIAN J, CHEVALIER C, et al. Expression of members of the calcium-binding S-100 protein family in a rat model of cerebralbasilar artery vasospasm［J］. J Neurosurg, 2002,97(2):408.
［9］王英振,王湘达. 人工全膝关节置换术的效果［J］. 青岛大学医学院学报, 2005,41(3):198-202.
