HIF1α在脑损伤中的作用及其机制的研究进展(4)

2025-06-14

  [12] Hamrick SE, McQuillen PS, Jiang X,et al.A role for hypoxiainducible factor1 alpha in desferoxamine neuroprotection[J]. Neurosci Lett, 2005, 379(2): 96100.

  [13] Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system[J].Nat Med,2003, 9: 677684.

  [14] Mazure NM, BrahimiHorn MC, Pouyssegur J. Protein kinases and the hypoxiainducible factor1, two switches in angiogenesis[J].Curr Pharm Des, 2003, 9: 53l541.

  [15] Hirota K. Hypoxiainducible factor 1, a master transcription factor of cellular hypoxic gene expression[J].J Anesth, 2002, 16: 150l59.

  [16] Liu LX, Lu H, Luo Y,et al.Stabilization of vascular endothelial growth factor mRNA by hypoxiainducible factor l[J].Biochem Biophys Res Commun, 2002, 291: 908914.

  [17] Gerber HP, Condorelli F, Park J,et al.Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes, Flt1, but not Flk1/KDR, is upregulated by hypoxia [J].J Biol Chem, 1997, 272: 2365923667.

  [18] Jones NM, Bergeron M. Hypoxia preconditioning induces changes in HIF1 target genes in neonatal rat brain[J].J Cereb Blood Flow Metab, 2001, 21(9): 11051114.

  [19] Papandreou I, Caims RA, Fontana L,et al.HIF1 mediates adaptation to hypoxia by actively down regulating mitochondrial oxygen consumption[J].Cell Metab, 2006, 3(3): 187197.

  [20] Kawakami M, Sekiguchi M, Sato K,et al.Erythropoietin receptormediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia[J].J Biol Chem, 2001, 276(42): 3946939475.

  [21] Keller M, Yang J, Griesmaier E,et al.Erythropoietin is neuroprotective against NMDAreceptormediated excitotoxic brain injury in new born mice[J].Neurobiol Dis, 2006, 24(2): 357366.

  [22] Digicaylioglu M, Garden G, Tinberlake S,et al.Acute neuroprotective synergy of erythropoietin and insulinlike growth factorⅠ[J].Proc Natl Acad Sci USA, 2004, 101(26): 98559860.

  [23] Baek JH, Jang JE, Kang CM,et al.Hypoxiainduced VEGF enhances tumor survivability via suppression of serum deprivationinduced apoptosis[J].Oncogene, 2000, 19(40): 46214631.

  [24] Zaman K, Ryu H, Hall D,et al.Protection from oxidative stressinduced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxiainducible factor 1 and ATF1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin[J].J Neurosci, 1999, 19(22): 98219830.

  [25] 于如同,高文昌,赵序元,等. 腺病毒介导低氧诱导因子1α基因对创伤性脑损伤后细胞凋亡的影响[J].实用临床医药杂志, 2004, 8(1): 2732.

  [26] Kin JY, Ahn HJ, Ryu JH,et al.BH3only protein Noxa is a mediator of hypoxic cell death induced by hypoxiainducible factor 1 alpha[J].J Exp Med, 2004, 199(1): 113124.

  [27] Lee MJ, Kim JY, Suk K,et al.Identification of the hypoxiainducible factor 1 alpharesponsive HGTDP gene as a mediator in the mitochondrial apoptotic pathway[J].Mol Cell Biol, 2004, 24(9): 39183927.

HIF1α在脑损伤中的作用及其机制的研究进展(4).doc 将本文的Word文档下载到电脑 下载失败或者文档不完整,请联系客服人员解决!

下一篇:可必特溶液雾化吸入治疗毛细支气管炎的临床观察

相关阅读
本类排行
× 游客快捷下载通道(下载后可以自由复制和排版)

下载本文档需要支付 7

支付方式:

开通VIP包月会员 特价:29元/月

注:下载文档有可能“只有目录或者内容不全”等情况,请下载之前注意辨别,如果您已付费且无法下载或内容有问题,请联系我们协助你处理。
微信:xuecool-com QQ:370150219