[9]Seeg er M A,Schiefner A,Eiche r T,et al.Structural
a sy mmetr y o f Acr B trim er sug g ests a peristaltic pump
mechanism[J].Science,2006,313(5791):1295
[10]Schuldiner S.St ructural bio lo g y:the ins and outs of dr ug
tra nspor t[J].N ature,2006,443(7108):156
[11]Daw so n R J P,Lo che r K P.Structur e o f a bacterial mul-
tidrug A BC tra nspo rter[J].N ature,2006,443(7198):
180
[12]Li X-Z,Liv ermo re D M,Nikaido H.Role o f efflux pump
(s)in intrinsic resistance o f Pseudomonas aeruginosa:
resista nce to tet racycline,chlor amph enico l,and nor-flo xacin[J].Antimicrob Agents Chemother,1994,38(8):
1732
[13]Li X-Z,M a D,Liv ermo re D M,et al.Ro le o f efflux
pump(s)in intrinsic resistance of Pseudomonas aerugi-nosa:activ e efflux as a contributing facto r toβ-lactam resista nce[J].Antimicrob Agents Chemother,1994,38
(8):1742
[14]N ikaido H.Prev entio n o f drug access to bacterial tar-
g ets:per mea bility ba r rier s and activ e efflux[J].Science,
1994,264(5157):382
[15]K lebba P E.T he po rino logist[J].J Bacteriol,2005,187
(24):8232
[16]李显志,张丽,凌保东,等.开发阻断细菌耐药机制的新型
抗菌药物[A].王浴生主编.化疗药理学与临床研究新进展[M].成都:四川大学出版社,2002:269
[17]Poo le K,L omov skaya O.Ca n efflux inhibito rs really
co unter resistance?[J].Drug Discovery Today:Thera-peutic Strate gies,2006,3(2):145
[18]M o rita Y,Cao L,Go uld G,et al.N alD encodes a seco nd
repr esso r o f th e M ex A B-O prM m ultidr ug efflux o per on of Pseudomonas aeruginosa[J].J Bacteriol,2006,188
·
199
·
中国抗生素杂志2007年4月第32卷第4期
(24):8649
[19]Pumbwe L,U eda O ,Yo shimura F,et al .Bacteroides
fragilis Bme ABC efflux sy stems additiv ely confer intrin-sic a ntimicro bial resistance [J].J Antimicrob Chemother ,2006,58(1):37
[20]M asi M ,Pag es J -M ,Pradel E .Pr oduction of the cr yptic
EefA BC efflux pump in Enterobacter aerogenes chlo ra m-phenicol -resistant mutants [J ].J Antimicrob Chemother ,2006,57(6):1223
[21]O gaw a W ,Ko tera saw a M ,Kuro da T ,et al .Kmr A mul-tidrug efflux pum p f rom K lebsiella pneumoniae [J].Biol Pharm Bull ,2006,29(3):550
[22]Yamada Y ,Shio ta S ,M izushima T ,et al .Functio nal
gene clo ning a nd char acteriza tio n of M de A,a multidr ug efflux pump fr om Staphy lococcus aureus [J ].Biol Pharm Bull ,2006,29(4):801
[23]T ruong-Bo lduc Q C,Strahilevit z J,Hoo per D C.N or C,
a new efflux pump reg ula ted by M g r A of Staphylococcus aureus [J].Antimicro
b Agents Chemother ,2006,50(3):1104
[24]Ya mada Y,H ideka K,Shio ta S,et al .Gene cloning a nd
cha racteriza tio n o f SdrM ,a chr omo somally -encoded mul-tidrug ef flux pump ,fro m Staphylococcus aureus [J ].Biol Pharm Bull ,2006,29(3):554
[25]Ro mano va N A ,W olffs P F ,Br ov ko L Y ,et al .Role of
efflux pumps in adapta tion and resista nce of Listeria monocytogenes to benzalko nium chlo ride [J ].Appl Envi -ron Microbiol ,2006,72(5):3498
[26]Piddo ck L J V.M ultidr ug -resistance efflux pumps-no t
just fo r r esistance [J ].N at Rev Microbiol ,2006,4(8):629
[27]Robicsek A ,Strahilevit z J ,Jacoby G A ,et al .Fluo ro-quinolone-mo difying enzy me :a new adaptatio n of a co m-mon amino g lyco side acetyltr ansfe rase [J ].N at Med ,2006,12(1):83
[28]Pa rk C H,Ro bicsek A,J aco by G A,et al .Pr ev alence in
the U nited States o f aac (6′)-Ib -cr enco ding a cipro flo -xacin-modifying enzyme [J].Antimicro b Agents Chemo -ther ,2006,50(11):3953
[29]Li X -Z .Q uino lone r esista nce in bac teria :emphasis on
plasmid-media ted mechanisms [J ].Int J Antimicrob
Agents ,2005,25(6):453
[30]Ro bicsek A,J aco by G A ,Ho oper D C.The wo rldwide
emerg ence of pla smid -mediated quinolo ne resistance [J ].L ancet I nf ect Dis ,2006,6(10):629
[31]W ang M ,T ran J H,Jacoby G A,et al .Plasmid-media -ted quinolo ne resistance in clinical isolates o f Escherichia coli f ro m Shanghai,China [J ].Antimicrob Agents Che -mother ,2003,47(7):2242
[32]Tr an J H,J aco by G A ,Hoo per D C.Inte ractio n o f the
plasmid -encoded quino lone resista nce pro tein Q nr with Escherichia coli DN A g y rase [J ].Antimicrob Agents
Chemother ,2005,49(7):118
[33]Hegde S S ,V etting M W ,Ro de rick S L ,et al .A fluo ro-quinolone r esistance pro tein fro m Mycobacterium tubercu -losis that mimics DN A [J ].Science ,2005,308(5727):1480
[34]李显志.细菌对喹诺酮类抗菌药物的耐药性-质粒介导的
耐药机制[J].中华医药卫生,2004,2(1):1
[35]J aco by G A,Wa lsh K E,M ills D M ,et al .qnrB ,a no th-er plasmid -mediated g ene for quino lo ne r esistance [J ].Antimicrob Agents Chemother ,2006,50(4):1178[36]Rodrig ue z -M ar tinez J M ,Poir el L ,Pascua l A ,et al .
Plasmid-mediated quinolo ne r esista nce in Aust ralia [J].Micro b Drug Resist ,2006,12(2):99
[37]Wa ng C X ,Cai P Q ,Guo Y ,et al .Emer ging plasmid -media ted quino lo ne resista nce a sso ciated with the qnrA gene in Entero bacter cloacae clinical isolates in China [J ].J Hosp Infect ,2006,63(3):349
[38]Chu Y W ,Cheung T K ,Ng T K ,et al .Q uino lo ne r esis-tance deter minant qnrA 3in clinical isolates of Salmonella
in 2000-2005in Hong Ko ng [J].J Antimicrob Chemo -ther ,2006,58(4):904
[39]Chen Y T,Shu H Y,Li L H,et al .Complete nucleo tide
sequence of pK 245,a 98-kilo ba se pla smid co nfer ring quinolo ne resista nce and ex tended-spect rum-β-lactamase activity in a clinical K lebsiella pneumoniae isolate [J].Antimicrob Agents Chemother ,2006,50(11):3861[40]潘晓娴,唐英春,廖康.质粒介导的克雷伯菌耐喹诺酮类
药物机制研究[J ].中国抗生素杂志,2006,31(5):295[41]王明贵,T ran J H,J aco by G,等.大肠埃希菌临床分离株
对喹诺酮类抗菌药的质粒介导耐药[J].中国感染与化疗杂志,2006,6(4)::217
[42]王春新,蔡培泉,黄支密,等.阴沟肠杆菌喹诺酮类耐药
qnr 基因的发现[J ].中华微生物学和免疫学杂志,2006,26(2):162
[43]Fur uy a E Y ,L ow y F D .Antimic robia l -resista nt bacteria
in the community se tting [J ].N at Rev Microbiol ,2006,4
(1):36
[44]汪复.社区获得甲氧西林耐药金葡菌[J ].中国感染与化
疗杂志,2005,5(6):376
[45]Diep B A ,Gill S R ,Chang R F ,et al .Co mple te g eno me
sequence o f U SA300,a n epidemic clone o f co mmunity -acquir ed me thicillin-resista nt Staphy lococcus aureus [J].L ancet ,2006,367(9512):731[46]Enrig ht M C.
Geno me of an epidemic co mmunity -·
200·2006年细菌对抗菌药物耐药机制研究进展回顾 李显志等
acquir ed M RS A[J].L ancet,2006,367(9512):705 [47]Go mes A R,W esth H,de Lencastre H.O rig ins and ev o-
lutio n o f me thicillin-resistant Staphylococcus aureus clo nal lineag es[J].Antimicrob Agents Chemother,2006,50
(10):3237
[48]Seidl K,Stucki M,Rueg g M,et al.Staphylococcus
aureus Ccp A a ffects vir ulence determina nt pr oduction a nd antibio tic r esista nce[J].Antimicro b A gents Chemother, 2006,50(4):1183
[49]Cho ng tra ko ol P,Ito T,M a X X,et al.Sta phyloco ccal
ca sset te chr omo so me mec(SCC mec)typing of me thi-cillin-resistant Staphylococcus aureus strains isolated in11
A sia n countries:a pro po sa l fo r a new nomencla ture fo r
SCC mec elements[J].Antimicro b Agents Chemother, 2006,50(3):1001
[50]N o to M J,Archer G L.A subset o f Staphylococcus
aureus st rains har boring staph ylo coccal cassette chr omo-so me mec(SCC mec)type IV is deficie nt in Ccr AB-medi-
a ted SCC mec ex cisio n[J].Antimicro
b Agents Chemother,
2006,50(8):2782
[51]Kehr enberg C,Sch war z S.Distributio n o f flo rfenicol
resista nce g enes fe x A a nd cf r amo ng chlo ramphenico l-resista nt Staphylococcus isolates[J].Antimicrob Agents Chemother,2006,50(4):1156
[52]Rio rdan J T,O′Lea ry J O,Gusta fso n J E.Contributio ns
of sigB and sarA to distinct multiple a ntimicro bial resis-tance mechanisms o f Staphylococcus aureus[J].Int J Antimicrob Agents,2006,28(1):54
